KEGG   Homo sapiens (human): 1760
Entry
1760              CDS       T01001                                 
Symbol
DMPK, DM, DM1, DM1PK, DMK, MDPK, MT-PK
Name
(RefSeq) DM1 protein kinase
  KO
K08788  dystrophia myotonica-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Disease
H00568  Myotonic dystrophy
Drug target
Baliforsen: D10907
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1760 (DMPK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     1760 (DMPK)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   1760 (DMPK)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr DMPK_coil Kinase-like FTA2 Kdo ABC1 Haspin_kinase CCDC138_cc CENP-F_N Tmemb_cc2 DUF3450 Laminin_II ATG16 APH Seadorna_VP7 CCDC22_CC
Other DBs
NCBI-GeneID: 1760
NCBI-ProteinID: NP_004400
OMIM: 605377
HGNC: 2933
Ensembl: ENSG00000104936
UniProt: Q09013 E5KR06
Structure
Position
19:complement(45769709..45782490)
AA seq 629 aa
MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR
LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER
DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV
MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP
EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP
LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG
ATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTP
MELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVL
TRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPS
PRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSR
AAALGCIGLVAHAGQLTAVWRRPGAARAP
NT seq 1890 nt   +upstreamnt  +downstreamnt
atgtcagccgaggtgcggctgaggcggctccagcagctggtgttggacccgggcttcctg
gggctggagcccctgctcgaccttctcctgggcgtccaccaggagctgggcgcctccgaa
ctggcccaggacaagtacgtggccgacttcttgcagtgggcggagcccatcgtggtgagg
cttaaggaggtccgactgcagagggacgacttcgagattctgaaggtgatcggacgcggg
gcgttcagcgaggtagcggtagtgaagatgaagcagacgggccaggtgtatgccatgaag
atcatgaacaagtgggacatgctgaagaggggcgaggtgtcgtgcttccgtgaggagagg
gacgtgttggtgaatggggaccggcggtggatcacgcagctgcacttcgccttccaggat
gagaactacctgtacctggtcatggagtattacgtgggcggggacctgctgacactgctg
agcaagtttggggagcggattccggccgagatggcgcgcttctacctggcggagattgtc
atggccatagactcggtgcaccggcttggctacgtgcacagggacatcaaacccgacaac
atcctgctggaccgctgtggccacatccgcctggccgacttcggctcttgcctcaagctg
cgggcagatggaacggtgcggtcgctggtggctgtgggcaccccagactacctgtccccc
gagatcctgcaggctgtgggcggtgggcctgggacaggcagctacgggcccgagtgtgac
tggtgggcgctgggtgtattcgcctatgaaatgttctatgggcagacgcccttctacgcg
gattccacggcggagacctatggcaagatcgtccactacaaggagcacctctctctgccg
ctggtggacgaaggggtccctgaggaggctcgagacttcattcagcggttgctgtgtccc
ccggagacacggctgggccggggtggagcaggcgacttccggacacatcccttcttcttt
ggcctcgactgggatggtctccgggacagcgtgcccccctttacaccggatttcgaaggt
gccaccgacacatgcaacttcgacttggtggaggacgggctcactgccatggtgagcggg
ggcggggagacactgtcggacattcgggaaggtgcgccgctaggggtccacctgcctttt
gtgggctactcctactcctgcatggccctcagggacagtgaggtcccaggccccacaccc
atggaactggaggccgagcagctgcttgagccacacgtgcaagcgcccagcctggagccc
tcggtgtccccacaggatgaaacagctgaagtggcagttccagcggctgtccctgcggca
gaggctgaggccgaggtgacgctgcgggagctccaggaagccctggaggaggaggtgctc
acccggcagagcctgagccgggagatggaggccatccgcacggacaaccagaacttcgcc
agtcaactacgcgaggcagaggctcggaaccgggacctagaggcacacgtccggcagttg
caggagcggatggagttgctgcaggcagagggagccacagctgtcacgggggtccccagt
ccccgggccacggatccaccttcccatctagatggccccccggccgtggctgtgggccag
tgcccgctggtggggccaggccccatgcaccgccgccacctgctgctccctgccagggtc
cctaggcctggcctatcggaggcgctttccctgctcctgttcgccgttgttctgtctcgt
gccgccgccctgggctgcattgggttggtggcccacgccggccaactcaccgcagtctgg
cgccgcccaggagccgcccgcgctccctga

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Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (20)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (63)   
   RefSeq(nuc) (17)   
   GenBank (23)   
   EMBL (23)   
3D Structure (2)   
   PDB (2)   
Protein domain (17)   
   Pfam (17)   
All databases (124)   

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